The cholesterol-lowering statin drug empire continues to crumble. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: Clipboard, Search History, and several other advanced features are temporarily unavailable. (It should be noted that doctors in Europe prescribe statins based on different parameters than doctors in the United States.) Recent controversy over statins could induce a large proportion of patients to stop their medication and generate a large number of major cardiovascular events. Dallas, TX 75390, © 2020 The University of Texas Southwestern Medical Center, A study published in the March 2019 Journal of the American Heart Association, "10 truths about statins and high cholesterol. The risk for heart disease increases as we age and almost everyone’s risk for ASCVD is greater than 7.5 percent by age 65.  |  Before conflicting studies and internet myths scare you away, let’s take a look at how we prescribe statins and their potential side effects. Get the latest public health information from CDC: or Call214-645-8300, Appointment Two British medical journals had accused each other of putting the public’s health in danger. If you are interested in finding out more information about statins and whether they are right for you or a loved one, call 214-645-8300 or request an appointment online. HHS In France, if the percentages of medication discontinuations following the controversy were actually similar to those we found in our survey, 4992 major cardiovascular events, including 1159 deaths, would be induced in 1 year. Most doctors would say no. 2010 Feb;32(2):300-10. doi: 10.1016/j.clinthera.2010.02.004. The controversy in the United Kingdom started in 2013 when the British Medical Journal (BMJ) claimed statins were being overprescribed to people with low risk of heart disease, and that the drugs’ side effects were worse than previously thought. Matthews A, Herrett E, Gasparrini A, Van Staa T, Goldacre B, Smeeth L, Bhaskaran K. BMJ. In September 2016, an article and editorial in The Lancet questioned the BMJ’s claims and accused the journal of causing “measurable harm to public health.” The BMJ responded by asking England’s chief medical officer to create an independent review of the evidence for statins. A long-simmering medical debate over a class of drugs used to lower cholesterol burst into the media spotlight across the pond in September 2016. How common and serious are the drugs’ side effects? Other side effects can include increased risk for diabetes and liver damage, but these are also quite rare. Before you refuse to take a statin or stop taking a statin, consult your doctor. Aims: BACKGROUND: The effect of statins on the prevention of cardiovascular events is well-established. Circ Cardiovasc Qual Outcomes. or 817-882-2700, 5323 Harry Hines Blvd. I don’t think anyone doubts statins save lives. cholesterol, Our first step in preventing or treating high cholesterol is with diet and lifestyle changes. The effect of statins on the prevention of cardiovascular events is well-established. Destiny's patient: A heart-stopping story of survival at UT Southwestern, Transradial angioplasty – a handy fix for blocked coronary arteries. Ferrajolo C, Arcoraci V, Sullo MG, Rafaniello C, Sportiello L, Ferrara R, Cannata A, Pagliaro C, Tari MG, Caputi AP, Rossi F, Trifirò G, Capuano A. PLoS One. A total of 142 patients were included: 37 in primary prevention (mean age, 68.0±13.1 years; 41% women); 105 in secondary prevention (mean age, 67.6±12.1 years; 20% women). New Patient Appointment However, a recent controversy in France questioned the value of statins, especially in primary prevention. Related reading: Medical misinformation: Vet the message! or 214-645-8300. or 214-645-8300, Appointment 2015 Sep;18(6):896-905. doi: 10.1016/j.jval.2015.06.002. The most common is muscle ache or pain. Despite these prolonged and often misguided debates, we know the benefits of taking a statin are enormous and largely invisible for people at high risk for heart disease. doi: 10.1136/bmj.i3283. Get our occasional alerts about new blog posts, upcoming events, opportunities, and more. Search Conditions & Treatments NLM Statins in the primary and secondary prevention of cardiovascular disease in women: facts and myths. Let’s stay in touch! Copyright © 2013 Elsevier Masson SAS. Only 10 percent declined statins, with most citing side effects as their main concern. In 2015, new research published in BMJ Open revealed that despite tens of millions more people being prescribed statins across many European countries there was no evidence that this had any effect on cardiovascular mortality, over a twelve year period. All patients on statins were recruited consecutively from consultations over a period of 1 month (from March 2013) by five physicians in three centres. COVID-19 Update: Information and resources can be found here. To evaluate the impact of this controversy on patient adherence to statin therapy and its potential clinical impact. Another belief held by some that I find puzzling is the notion that physicians have a personal financial interest in giving their patient a statin (or other drug). Methods: British tabloid the Daily Mail called it the “statins war.”. Appointment Refine your search: Pattern of statin use in southern italian primary care: can prescription databases be used for monitoring long-term adherence to the treatment. COVID-19 is an emerging, rapidly evolving situation. Find a Location, Appointment Typically, we can eliminate the muscle aches by changing the dose of the statin or switching to a different statin, as the molecular structures of statin medications can be quite different. Use the American Heart Association’s heart disease risk calculator to start a conversation with your doctor about your personal risk. Find a Doctor 2016 Jun 28;353:i3283. Data from the 2008 JUPITER Trial suggest a 54 percent heart attack risk reduction and a 48 percent stroke risk reduction in people at risk for heart disease who used statins as preventive medicine. statins, Statins appear to be significantly more effective in preventing heart attacks in patients who have already had coronary artery disease, including heart attacks or angina (secondary prevention). New Patient Appointment Persell SD, Brown T, Lee JY, Shah S, Henley E, Long T, Luther S, Lloyd-Jones DM, Jean-Jacques M, Kandula NR, Sanchez T, Baker DW. Our goal is to decrease your risk of heart disease, heart attack, and stroke. Skip to Page Content. Skip to Site Navigation Value Health. For years, we prescribed statins such as atorvastatin (Lipitor) and rosuvastatin (Crestor) almost solely based on a target cholesterol level. In 1 out of 10,000 cases, a patient on a statin will develop serious pain and muscle damage. So what’s the debate? 2013 Aug;64(6):411-6. doi: 10.1177/0003319712451115. BMC Health Serv Res. Conclusion: This is so rare that I’ve never seen it in a patient. Get the latest research from NIH: Impact of Statin Adherence on Cardiovascular Morbidity and All-Cause Mortality in the Primary Prevention of Cardiovascular Disease: A Population-Based Cohort Study in Finland. All rights reserved. Epub 2015 Nov 10. This site needs JavaScript to work properly. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. We know these changes can be difficult to make, but statin therapy is not an alternative to healthy eating and exercise. The guidelines, which were updated in November 2018 and published in the journal Circulation, now emphasize a balance between LDL numbers and assessing cardiovascular disease. This article, originally published in 2016, was updated April 3, 2019. A study published in the March 2019 Journal of the American Heart Association reported that more than half of patients eligible for statins do not receive them. Epub 2012 Jun 25. Author information: (1)Division of Coronary Artery Disease and Intensive Cardiac Care, Georges-Pompidou European Hospital, Assistance Publique des Hôpitaux de Paris (AP-HP), University Paris-Descartes, 20, rue Leblanc, 75015 Paris, France.

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