What is nonalcoholic fatty liver disease (NAFLD)? Introduction. NAFLD can be harmless, but sometimes it may cause the liver to swell. Nonalcoholic fatty liver disease (NAFLD) is a common and increasingly recognized disorder characterized by macrovesicular accumulation of fat in hepatocytes, usually found in association with obesity, insulin resistance, and hyperlipidemia. Nonalcoholic fatty liver disease is a spectrum of liver diseases composed of nonalcoholic fatty liver and nonalcoholic … Nonalcoholic fatty liver disease (NAFLD) is a growing worldwide epidemic and an important risk factor for the development of insulin resistance, type 2 diabetes, nonalcoholic steatohepatitis (NASH), and hepatic cellular carcinoma (HCC). The pathogenesis of steatosis and cellular injury is thought to be related mostly to insulin resistance and oxidative stress. Nonalcoholic fatty liver disease (NAFLD) affects up to 30% of adults and is the most common liver disease in Western nations. Beyond prevention programs which are of particular interest because of the increasing number of overweight children, treatment should be focussed on the most important risk factors, obesity and insulin resistance. Therefore, management entails identification and treatment of metabolic risk factors, improving insulin sensitivity, and increasing antioxidant defences in the liver. Nonalcoholic fatty liver disease is characterized by excessive fat accumulation in the liver (hepatic steatosis). Over time, this swelling can cause scarring in your liver (cirrhosis). Nonalcoholic fatty liver disease (NAFLD) is the most common cause for elevated liver enzymes in the developed nations. Nonalcoholic fatty liver disease (NAFLD) is the primary cause of chronic liver disease in the United States, afflicting an estimated 80 to 100 million Americans. Fatty liver disease means that you have fat inside your liver that can, over time, affect liver function and cause liver injury. Nonalcoholic fatty liver disease (NAFLD) is a buildup of fat in the liver. The more scarring your liver has, the worse it functions. NAFLD is associated with central adiposity, insulin resistance, type 2 diabetes mellitus, hyperlipidemia, and cardiovascular disease. It is a common condition. Non-alcoholic fatty liver disease (NAFLD) is common and may progress to cirrhosis and its complications. Despite the prevalence of NAFLD, lifestyle interventions involv … Nonalcoholic fatty liver disease (NAFLD) is a common condition characterized by the accumulation of fat, mainly triglyceride (TG), within the liver [Angulo, 2002].It is histologically identical to alcohol-induced liver injury, but occurs in individuals who do not consume alcohol in excess. Health care providers divide fatty liver disease into two types. This condition occurs in both adults and children, People who drink too much alcohol may also have fat in their liver, but that condition is different from fatty liver disease. Types of fatty liver disease.
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