When it comes to headache or nausea, for instance, "if I told you hypothetically that statins can prevent five heart attacks but cause five people to get mild headaches, are those equal?" Statins are a class of drug that inhibit one of the first steps in cholesterol synthesis, in turn upregulating LDL receptors and lowering LDL-C generally by 25-50%. Very rarely, statins can cause life-threatening muscle damage called rhabdomyolysis (rab-doe-my-OL-ih-sis). The use of statins is increasing in the United States. All rights reserved. In addition to increased statin dosage, several other medications, age and genetic factors can put patients at higher risk of having an adverse effect. The finding raises the question: Are statins overprescribed for the prevention of cardiovascular disease? Dangers of Statin Drugs. The Cholesterol Treatment Trialists' (CTT) meta-analysis using 27 large-scale trials demonstrated that each ~40 mg/dL (1 mmol/L) reduction in LDL-C with statin therapy decreases risk of major vascular events by ~25% each year after the first year; there was a more modest 10-12% reduction in the first year. With the decline of smoking, LDL-C control has become an even more important way to decrease the risk for ASCVD events (heart attacks and strokes). In general, statins are very well tolerated and about 85-90% of patients report no side effects. People with LDL levels of 100 or lower "tend to have lower rates of heart disease and stroke, supporting a 'lower is better' philosophy," according to a, A level of above 160 is considered "very high," according to a, The main takeaway from the new study and the new cholesterol guidelines is that "the threshold for starting statins in primary prevention is a complex one and must be individualized to the patient," said Dr. Michael Blaha, an associate professor and director of clinical research at the. 1. Dangers of Statin Drugs. Patients with high cholesterol develop plaque in their blood vessels, which can limit blood flow and lead to ASCVD events. While the side effects of statins are important to keep in mind, overall, the benefits of lowering LDL with statins far outweigh the low likelihood of an adverse effect for the vast majority of adults at elevated risk for ASCVD. Out of 10,000 patients treated for five years, only 5-10 patients may have a hemorrhagic stroke, which pales in comparison to the reduction in ischemic stroke seen with LDL-C reduction. The occurrence of new-onset diabetes went up when patients had one or more pre-existing risk factors for diabetes. Let’s look at the top 5 ways that statins can wreak havoc on your health. The study analyzed the benefits and risks only when using statins for the primary prevention of cardiovascular disease, including heart attacks and stroke, not when used after a heart attack, for example. The recommendations also address many of the concerns raised when the guidelines were last updated five years ago. "It really depends on age, gender and the type of overall health status," Puhan said. Believe it or not, statins affect way more than just your cholesterol – they can damage your immune system too, impairing your body’s protection against illness and disease. Age and a mutation in the SLCO1B1 gene can also slow statin breakdown. The study had some limitations, including that it involved data on only the four most commonly prescribed statins and that the balance of risks and benefits was measured only for the US, the UK and Switzerland. Providers should also be careful of factors that can increase the risk of side effects presenting in a patient, especially interacting medications. Besides the fact that statins completely ignore the root of the issue (what caused the high cholesterol in the first place), there are also a slew of statin drug side effects. Let’s look at the top 5 ways that statins can wreak havoc on your health. Khera often counsels his own patients about their statin prescriptions. When you take these statin drugs, the common complaints that people have is they have loss of energy, inability to focus and think clearly, they get muscle spasms, they get muscle aches, they get joint and muscle pains, they feel terrible on these drugs, and they can’t think as well. Feb 05 2018. The risk of very serious side effects is extremely low, and calculated in a few cases per million people taking statins. Puhan and his colleagues are planning to publish a followup study exploring risks and benefits within several other countries. For the vast majority, that won't happen, and it generally goes away when we stop the statin," Khera said. The data were used to estimate risk-benefit across populations in the United States, the United Kingdom and Switzerland. Many physicians recommend that patients have conversations about the risks and benefits of statins with their doctors. Another limitation of the study is that "the side effect data from randomized controlled trials are not ideal because trials are short-term and not ideal for capturing harms, so we tried to address that by including observational studies," Puhan said. Fear of adverse effects should not prevent a healthcare provider from prescribing a statin, though it is important to be alert for a severe reaction to a statin and take it seriously. "Statins can cause muscle aches, but even if it's as high as one in 10 who get muscle aches, that means 9 in 10 will not. Updated 2239 GMT (0639 HKT) December 3, 2018. Since 1900, ASCVD has been the leading cause of death every year in the US (except for 1918, the year of the influenza pandemic). The Panel critically appraised the data and agreed by consensus on the categorization of reported adverse effects. "That is why it is critical to conduct careful risk assessment and consider patient preferences before initiating statin therapy.". For instance, as a side effect, "cancer is not well-established, by any means. Dangers des statines Les statines présentent des effets secondaires qui ne sont pas négligeables. However, there are a few side effects that tend to raise concern among patients when considering the need for one these medications. One study aims to help doctors and patients decide, remove mentions of needing routine liver monitoring, New cholesterol guidelines offer a more personalized approach, statement from the American Heart Association and American College of Cardiology, Johns Hopkins Ciccarone Center for the Prevention of Heart Disease.
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